Damien Thorn is dead, but his prophecy is reborn in a mysterious girl named Delia, who is adopted by two attorneys, Gene & Karen York. When Karen realizes her baby was born under suspicious circumstances, she hires a private investigator to find Delia's real parents. A series of bizarre accidents occur, and Karen begins to suspect everyone of conspiring against her as she unravels the truth about her baby.

From the Pulitzer Prize-winning author of "The Hours" comes a story that chronicles a dozen years in the lives of two best friends who couldn't be more different. From suburban Cleveland in the 60s, to New York City in the 80s, where they meet an older woman, the film charts a journey of trials, triumphs, loves and losses. Now the question is: can they navigate the unusual triangle they've created and hold their friendship together?